Product Description
Pueraria root Extract. Pueraria lobata(Willd.)Ohwi Pueraria Lobata Extract;EINECS:N/A;CAS:223748-08-1 Dry Root Isoflavones.40~70%HPLCPuerarin 98%99%HPLC

Product Feature
A.Coronary and Cerebral Vasodilatory Effects:

The decoction or ethanol extract of Gegen (which contains total flavones, daidzin, and Puerarin) upon being administered to rats intraperitoneally or subcutaneously antagonized acute myocardial ischemia induced by pituitrin. The injection of Puerarin caused a marked increase in the coronary flow and a decrease in vascular resistance. During intravenous injection, the blood flow of the internal carotid and femoral arteries was also increased, though not as markedly as that in the coronary vessels. The inability of reserpine to modify the action of the total flavones and Puerarin on coronary circulation indicates a direct relaxant action on the vascular smooth muscle. Puerarin was more potent than the total flavones. Intravenous injection of Puerarin in anesthetized dogs decreased the heart rate and the total peripheral resistance, slightly decreased the left ventricular work, reduced the myocardial oxygen consumption, and increased the myocardial efficiency. The cardiac output, however, was not significantly altered. These effects were beneficial to the maintenance of equilibrium between myocardial oxygen demand and supply [3]. IV injection of extract of Gegen in anesthetized dogs with acute myocardial infarction induced by ligation of the anterior descending coronary artery caused a significant decrease in blood pressure, a slowing of the heart beat, and a slight decrease in blood flow in the infarcted area. At the same time, it caused no significant change in the arterial blood oxygen, but significant increase in the venous blood oxygen at the coronary sinus and infracted area. The oxygen utilization and consumption, as well as lactic acid content, in both the normal and infarcted areas were markedly decreased. Whereas lactic acid utilization was markedly increased. These results indicate that Puerarin has excellent effects on the metabolism of infarcted myocardium. Injection of total flavones to the internal carotid artery of anesthetized dogs causes a dose-dependent increase in the cerebral blood flow and a decrease in cerebral vascular resistance.


B.Hypotensive Effects:

Pueraria's total flavones can causes hypertensive dogs and normotensive anesthetized dogs to lower their blood pressure. In hypertensive dogs, the pressure response to norepinephrine and the hypotensive effect of acetylcholine could be attenuated by the ethanol extract of Gegen. It has a direct vasodilatory action, which decreases the peripheral vascular resistance. It can also decrease the blood catecholamine level and vascular reactivity. This may be the reason why it can be effectively used for treating migraine headaches.

C.Inhibition of Platelet Aggregation:

ADP-induced rat platelet aggregation was inhibited to different extents by 0.25, 0.5, and 1.0 mg/ml of Puerarin in vitro, and also intravenous injection. At doses of 0.5 ~ 3.0mg/ml, Puerarin also inhibited (in vitro) aggregation of rabbit and sheep platelets, and those of normal subjects induced by ADP or serotonin. It can also inhibit secretion of serotonin from platelets. This effect is favorable to the prevention and treatment of angina pectoris and myocardial infarction.

D.b-Adrenergic Blocking Effect:

In various isolated tissues with Beta-Adrenergic receptors, this herbal extract exhibited different degrees of significant antagonism against the effect of isoproterenol. This fact suggested that it is a wide spectrum beta blocker. The extract of Gegen at doses as low as 15 mg markedly attenuated the stimulant effect of 5 ug of isoproterenol on the isolated heart. Whereas tenfold the above dose had practically no direct inhibitory effect on normal hearts, nor does it influence the cardiotontic effect of digitalis glycosides. The findings suggest that the herb has selectivity to the beta1-receptors. The beta2-receptor blocking action was found to be weak because doses up to 150 mg were required in order to antagonize bronchodilation and peripheral vasodilation induced by isoproterenol

Product Specification/Models
Description: Pueraria root Extract,Isoflavones,Puerarin.
Plant Part Used: Dry root of Pueraria lobata (Willd.)ohwi
Specification: Isoflavones.40%UV;40%60%80%HPLC,Puerarin 98%~99%HPLC
Serie Code: S-026.
Expiration Date: 18~24Months in Good Condition
Storage Stock: Bulk in Stock
Pricing Terms: C&F;CIF;DDU;DDP.
Delivery Arrange: Soonest on the Day Confirmed

Appearance Showing: Yellow Brown or similar White to White Fine Powder
Extracts State: Fine Crystal Powder
Mesh Size: 100% Pass 80 Mesh Screen
Color: Yellow Brown or similar White to White
Odor and Smell: Characteristics.
Taste Sense: Characteristics.
Bulk Density: 0.44~0.46g/ml.
PH Value: 3.5~5.5.


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Application
Orally administered Puerarin was rapidly but incompletely absorbed in rats. IV injection of this substance was found highest in concentration in the kidney, lower in plasma, liver, and spleen, and lowest in the brain. It was minimally destroyed in the gastrointestinal tract, and it was metabolized in the blood, liver, and kidneys. Also, it can bind to the proteins of liver, kidneys, lungs and plasma. The 24-hour urinary and fecal excretion of the oral dose of Puerarin accounted for 1.85 and 35.7% respectively. The data showed that after administered, it was rapidly distributed and eliminated, with low accumulation.
Properties:Pungent and sweet in flavor, cool in nature, it is related to the spleen and stomach channels.

Functions:Expels pathogenic factors from muscles and skin to reduce fever, promotes eruption, promotes the production of body fluids to quench thirst and invigorates the vital functions to relieve diarrhea.
It is spasmolytic, antipyretic, secretory, and anti-diarrheal. It is also thought to induce the eruption of measles at the early stage;
The herb is used in China to treat fever, headache, stiffness of back and neck, dry mouth in diarrhea or dysentery, and early-stage measles.
Treats angiocardiopathy. A scavenger of reactive oxygen species and inhibitor of LDL oxidation. It has potential effect to prevent atherosclerosis

Remedy For:Coronary heart disease,Angina pectoris,Cardiac infarction,Ocular fungus vascular diseases,Sudden deafness,Vascular diseases,Alcohol withdrawal support

Other Information

Pueraria root Chemical Composition:

The herb contains the flavonoids including:Puerarin,Puerarin-xyloside,Daidzin,daidzein,Daidzein-4,7-diglucoside;puerarin-7-xyloside;beta-Sitosterol;4`,6"-O- diacetylpuerarin,Arachidic acid;kudzu starch(fresh kudzu contain about 19%~20% kudzu starch,dry root contain about 10%-14% starch),allantoin;6,7-dimethoxycoumarin;daucosterol;5-methy-hydrantoin,pueroside A,pueroside B.

Nutritional Value::
Pueraria root(kudzu root) rich of amino acid,especially contain necesarry amino acid(calculate as per 100grams dry root):lisine 10mg,Methionine 7.54mg,Phenylalanine 9.65mg,Threonine 9.63mg,leucine 11.54mg,Valine 11.24mg,Histidine 6.74mg,also contain good minerals such as selenium,zinc,manganese,germanium,etc.


Isoflavones Group: Daidzin;daidzein; Puerarin; Daidzein-4,7-diglucoside;Genistein 8-c apiofuranosyl-glucopyranoside; Genistein; Genistin;coumestrol; Isoliquiritigenin; Formononetin; PG-1;PG-3; etc.

Xylopuerai Group: including Xylopuerai A;Xylopuerai B;Xylopuerai C,etc.

Triterpenoid Group: contains kudzusapogenol A;kudzusapogenol B;kudzusapogenol C; kudzusapogenol B methylvester; sapogenol;sophoradiol;Cantoniensistro; Kundz apogenol B;Kundzsapogenol C;

Alkaloid Group: Choline Chloride;Tannins,daucosterol,etc.

Other Phytochemicals:

Daidzin;daidzein; Daidzein-4,7-diglucoside; formononetin-7-glucoside;Genistein; formononetin; puerin-xyloside;4''-methoxy puerarin; 7-(6-o-malonyl-beta-D-glucopyranosyloxy)-4-3-(4-hydroxyphenly)-4H-1-benzopyran-4-one;6-hydroxy-7-methoxy-8-glucosyloxy-(3-glucosyloxy-4-xylosyl glucosyloxyp heny)-4H-benzopyran-4-one; allantoin; beta-sitosterol; daucosterol; arachidic acid; 6,7-dimethoxy coumarin; 5-methyl hydantoin,etc.

Main Content:Puerarin[3681-99-0]
Formula: C21 H20O9. Molecular Weight:115.1316
CAS RN:3681-99-0 Melting Point:228 - 233
Major Constituents Used:Puerarin ,Daidzein, Daidzin, Genistein, Genistin, Glycitein, Glycitin


Reference Link: Click for more Details

Payment
tt

Delivery
soon

Origin
China

Minimum Order
1kgs

Packaging
25kgs/drum

Inspection
HPLC

Samples
Free

Sample Price
US$0