Hawthorn Berry Extract.Hawthorn Leaf Extract. Crataegus monogyna; Crataegus cuneata Sieb, et Zucc. Crataegus Monogyna Extract;EINECS:289-914-0 CAS:90045-52-6 Berry or Leaves Berry Hydro-Alcoholic Extract: 10:1 TLC; Leaf Extract:Vitexin-2"-O-rhamnoside 2%HPLC.
High-performance liquid chromatographic determination of oligomeric procyanidins from dimers up to the hexamer in hawthorn.:
An HPLC method using UV diode array detection was developed for analysing procyanidins qualitatively and quantitatively up to the hexameric level in hawthorn samples. The analysed compounds included procyanidin dimers B-2, B-4 and B-5, procyanidin trimers C-1, epicatechin-(4beta-->8)-epicatechin-(4beta-->6)-epicatechin and epicatechin-(4beta-->6)-epicatechin-(4beta-->8)-epicatechin, a tetramer D-1 and a pentamer E-1 both consisting of (-)-epicatechin units linked through C-4beta/C-8 bonds. The concentrations of two unknown tetramers and a hexamer F were also quantified. The oligomeric procyanidins (OPs) were specifically determined due to the development of a method for isolating them from hawthorn during sample preparation. The pattern of oligomeric procyanidins in the leaves, flowers and fruits was similar, but the concentrations varied depending on the part of the plant. The concentration in leaves was 1.6%, in flowers 1.2% and in fruits 0.2% of the dry mass. The method was validated with respect to repeatability, recovery, linearity, and sensitivity. The repeatability for the quantitative analytical method of all the OPs in leaves was 7.7%, in flowers 8.8%, and in fruits 12.3%. The recovery of the main OPs ranged from 91 to 97%. The correlation coefficients of calibration curves were between 0.997 and 1.000. The limits of quantitation for different procyanidin standards were 0.05-0.12 mg/ml, when 10 microl of each standard solution was injected into the HPLC.
Isolation and identification of oligomeric procyanidins from Crataegus leaves and flowers.:
Oligomeric procyanidins were isolated from the leaves and flowers of hawthorn (Crataegus laevigata). A trimer, epicatechin-(4 beta-->8)-epicatechin-(4 beta-->6)-epicatechin, and a pentamer consisting of (-)-epicatechin units linked through C-4 beta/C-8 bonds have been isolated from hawthorn for the first time, in addition to known procyanidins including dimers B-2, B-4 and B-5, trimers C-1 and epicatechin-(4 beta-->6)-epicatechin-(4 beta-->8)-epicatechin, and tetramer D-1. A fraction containing a hexamer was also found.
Description: Hawthorn Fruit P.E.
Plant Part Used: Fruit or Leaves
Content Standardized: Fruit 10:1 Vitexin-2"-0-rhamnoside 2%HPLC
Serie Code: S-050
Expiration Date: 18~24Months in Good Condition
Storage Stock: Bulk in Stock
Pricing Terms: C&F;CIF;DDU;DDP.
Delivery Arrange: Soonest on the Day Confirmed
Appearance Showing: Light Red Brown Fine Powder
Extracts State: Fine Crystal Powder
Mesh Size: 100% Pass 80 Mesh Screen
Color: Light Red Brown
Odor and Smell: Charateristics Aromatic
Taste Sense: Flavour with Characteristics,light sweet.
Bulk Density: 0.52g/ml.
Common Benefit of Hawthorn:
Used to promote the health of the circulatory system, treat angina, high blood pressure, congestive heart failure and cardiac arrhythmia and has been found to strengthen the heart. Hawthorn is widely regarded in Europe as a safe and effective treatment for the early stages of heart disease and has been used for a number of ailments including angina, myocarditis, arteriosclerosis, nervous conditions like insomnia, and diarrhea. It has also been indicated for strengthening blood vessels, vascular insufficiency and blood clots, restoring the heart muscle wall, lowering cholesterol and to aid digestion.
Treatment for the early stages of heart disease :
Hawthorn is widely regarded in Europe as a safe and effective treatment for the early stages of heart disease and is endorsed by Commission E- the branch of the German government that studies and approves herbal treatments. It is used to promote the health of the circulatory system and has been found useful in treating angina, high blood pressure, congestive heart failure and cardiac arrhythmia. It has been found to strengthen the heart and stabalise it against arrythmias.
Cardiovascular system improvement:
There is also evidence for cardiovascular system improvement, particularly in clinical parameters associated with angina, congestive heart failure and acute myocardial infarct. This may be due to the herb''s antioxidant activity. Its use in the treatment of hepatitis in modern Chinese medicine is supported by the demonstration of hepatoprotective activity in animal studies.
Animal and laboratory studies have found that hawthorn contains active compounds with antioxidant properties. Antioxidants are substances that scavenge free radicals; damaging compounds in the body that alter cell membranes, tamper with DNA, and even cause cell death. Free radicals occur naturally in the body, but environmental toxins (including ultraviolet light, radiation, cigarette smoking, and air pollution) can also increase their number.
Free radicals are believed to contribute to the ageing process as well as the development of a number of health problems including heart disease. Antioxidants found in hawthorn can neutralise free radicals and may reduce or even help prevent some of the damage they cause.
Congestive heart failure:
Hawthorn has primarily been studied in people with congestive heart failure (a health condition in which the heart is unable to pump adequate amounts of blood to other organs in the body). Of six well-designed trials, four studies concluded that hawthorn significantly improved heart function and three found that the herb improved patients'' ability to exercise. Patients in five of the six studies reported that hawthorn significantly improved symptoms of the disease (such as shortness of breath and fatigue). One study found that hawthorn extract (900 mg/day) taken for 2 months was as effective as low doses of captropril (a leading heart medication) in improving symptoms of congestive heart failure. A large-scale international study is currently underway to determine whether hawthorn extract reduces the risk of death in people with this disease.
Animal and laboratory studies demonstrate that this herb has antioxidant properties that help protect against the formation of plaques, which leads to a health problem known as atherosclerosis. Plaque buildup in the vessels that supply the heart with oxygen-rich blood may cause chest pain (angina) and heart attacks while plaque buildup in the arteries that supply blood to the brain may result in stroke.
Hawthorn berry preparations have been shown to combat chest pain (angina), a health problem caused by insufficient blood flow to the heart. In one early study, 60 angina patients were given either 180 mg/day of hawthorn berry-leaf-flower extract or placebo for 3 weeks. Those who received the hawthorn preparation experienced improved blood flow to the heart and were also able to exercise for longer periods of time without suffering from chest pain.
Studies using rats suggest that a hawthorn tincture (made from the berries) may be a powerful agent for the removal of LDL ("bad") cholesterol from the bloodstream. The tincture of hawthorn berries also reduced the production of cholesterol in the liver of rats who were being fed a high-cholesterol diet. Studies to determine if hawthorn will confer the same effects in people are needed.
High blood pressure:
Although hawthorn has not been studied specifically in people with high blood pressure, considerable evidence supports the cardiovascular benefits of this herb. Studies suggest that hawthorn can be taken safely by people with hypertension who are also taking blood pressure medications.